AL Amyloidosis for the Cardiologist and Oncologist
نویسندگان
چکیده
منابع مشابه
Cardiac Amyloidosis Determines the Prognosis of Systemic Amyloidosis; Roles and Responsibilities of Cardiologist
Cardiac amyloidosis is a prognostically critical condition, since it is a frequent cause of death in patients with systemic amyloidosis. Lee et al. reported, for the first time, describing systemic amyloidosis in Korea from the perspective of cardiologists. In this paper, the authors enrolled 129 systemic amyloidosis patients retrospectively from 1999 to 2011. They showed that cardiac involve w...
متن کاملAL Amyloidosis
UNLABELLED DEFINITION OF THE DISEASE: AL amyloidosis results from extra-cellular deposition of fibril-forming monoclonal immunoglobulin (Ig) light chains (LC) (most commonly of lambda isotype) usually secreted by a small plasma cell clone. Most patients have evidence of isolated monoclonal gammopathy or smoldering myeloma, and the occurrence of AL amyloidosis in patients with symptomatic multip...
متن کاملthe search for the self in becketts theatre: waiting for godot and endgame
this thesis is based upon the works of samuel beckett. one of the greatest writers of contemporary literature. here, i have tried to focus on one of the main themes in becketts works: the search for the real "me" or the real self, which is not only a problem to be solved for beckett man but also for each of us. i have tried to show becketts techniques in approaching this unattainable goal, base...
15 صفحه اولBortezomib for AL amyloidosis: moving forward.
Small plasma cell clones can cause big problems2; this could be the outline for AL amyloidosis. AL amyloidosis is the most common form of systemic amyloidosis, a protein misfolding disease that is characterized by the failure of the amyloidogenic monoclonal light chain to adopt a soluble conformation. This misfolding leads to the formation of a precursor protein that tends to form highly organi...
متن کاملAutologous Stem Cell Transplant for AL Amyloidosis
AL amyloidosis is caused by clonal plasma cells that produce immunoglobulin light chains which misfold and get deposited as amyloid fibrils. Therapy directed against the plasma cell clone leads to clinical benefit. Melphalan and corticosteroids have been the mainstay of treatment for a number of years and the recent availability of other effective agents (IMiDs and proteasome inhibitors) has in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JACC: CardioOncology
سال: 2019
ISSN: 2666-0873
DOI: 10.1016/j.jaccao.2019.08.002